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DKC1 Antibody (MA5-35509) in IHC (P)
Immunohistochemistry analysis of DKC1 in paraffin-embedded mouse testis. Samples were incubated with DKC1 Monoclonal antibody (Product # MA5-35509) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
MA5-35509
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC1063
抗原
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human DKC1 (O60832)
偶联物
形式
Liquid
浓度
0.42 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2849409
产品详细信息
Immunogen sequence: VMKDSAVNAI CYGAKIMLPG VLRYEDGIEV NQEIVVITTK GEAICMAIAL MTTAVISTCD HGIVAKIKRV IMERDTYPRK WGLGPKASQK KLMIKQGLLD K
靶标信息
This gene is a member of the H/ACA snoRNPs gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the NOLA1, 2 and 3 proteins. The protein encoded by this gene and the three NOLA proteins localize to the dense fibrillar components of nucleoli and to coiled bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The protein encoded by this gene is related to the Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins. The gene lies in a tail-to-tail orientation with the palmitoylated erythrocyte membrane protein gene and is transcribed in a telomere to centromere direction. Both nucleotide substitutions and single trinucleotide repeat polymorphisms have been found in this gene. Mutations in this gene cause X-linked dyskeratosis congenita, a disease resulting in reticulate skin pigmentation, mucosal leukoplakia, nail dystrophy, and progressive bone marrow failure in most cases. Mutations in this gene also cause Hoyeraal-Hreidarsson syndrome, which is a more severe form of dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CBF5 homolog; dyskeratosis congenita 1, dyskerin; dyskeratosis congenita 1, dyskerin homolog; Dyskerin; H/ACA ribonucleoprotein complex subunit 4; H/ACA ribonucleoprotein complex subunit DKC1; Nopp140-associated protein of 57 kDa; Nucleolar protein family A member 4; Nucleolar protein NAP57; snoRNP protein DKC1
基因别名: BC068171; CBF5; DKC; DKC1; DKCX; NAP57; NOLA4; XAP101
UniProt ID: (Human) O60832, (Rat) P40615, (Mouse) Q9ESX5
Entrez Gene ID: (Human) 1736, (Rat) 170944, (Mouse) 245474
telomerase activity
RNA binding
protein binding
pseudouridine synthase activity
box H/ACA snoRNA binding
poly(A) RNA binding
telomerase RNA binding
isomerase activity
pivalyl-CoA mutase activity
o-hydroxylaminobenzoate mutase activity
lupeol synthase activity
beta-amyrin synthase activity
baruol synthase activity
centromere DNA-binding protein
chromatin/chromatin-binding, or -regulatory protein
box H/ACA snoRNA 3'-end processing
rRNA processing
RNA processing
telomere maintenance via telomerase
cell proliferation
rRNA pseudouridine synthesis
snRNA pseudouridine synthesis
positive regulation of telomere maintenance via telomerase
positive regulation of telomerase activity
telomerase RNA stabilization
positive regulation of establishment of protein localization to telomere
positive regulation of telomerase RNA localization to Cajal body
mRNA pseudouridine synthesis
pseudouridine synthesis
RNA-dependent DNA biosynthetic process
box H/ACA snoRNA metabolic process
rRNA modification
RNA modification
ribosome biogenesis
DNA biosynthetic process
