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产品信息
H00001749-M12
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
3B11
抗原
DLX5 (NP_005212, 191 a.a. approximately 279 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: KIKKIMKNGE MPPEHSPSSS DPMACNSPQS PAVWEPQGSS RSLSHHPHAH PPTSNQSPAS SYLENSASWY TSAASSINSH LPPPGSLQH
靶标信息
This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: distal-less homeo box 5; DLX-3; Homeobox protein DLX-3; Homeobox protein DLX-5; RDLX; split hand/foot malformation type 1 with sensorineural hearing loss
基因别名: AI385752; DLX5; RDLX; SHFM1D
UniProt ID: (Human) P56178, (Rat) P50575, (Mouse) P70396
Entrez Gene ID: (Human) 1749, (Rat) 25431, (Mouse) 13395
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription regulatory region DNA binding
HMG box domain binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
homeodomain transcription factor
skeletal system development
osteoblast differentiation
endochondral ossification
transcription from RNA polymerase II promoter
nervous system development
axon guidance
cell proliferation
embryonic limb morphogenesis
BMP signaling pathway
epithelial cell differentiation
inner ear morphogenesis
positive regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
anatomical structure formation involved in morphogenesis
positive regulation of epithelial cell proliferation
palate development
olfactory pit development
face morphogenesis
cellular response to BMP stimulus
positive regulation of canonical Wnt signaling pathway
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
transcription, DNA-templated
regulation of transcription, DNA-templated
axonogenesis
ear development
positive regulation of transcription from RNA polymerase II promoter
head development
bone morphogenesis
ossification
multicellular organism development
