Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 2
DMAP1 Antibody (MA5-53098) in WB
Western Blot analysis of DMAP1. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with DMAP1 recombinant monoclonal antibody (Product # MA5-53098) with a dilution of 1:5,000, followed by HRP-conjugated goat anti-rabbit secondary antibody with a dilution of 1:20,000. Image was developed using FeQTM ECL Substrate Kit.
产品信息
MA5-53098
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
23GB5680
抗原
A synthesized peptide derived from human DMAP1 (411-467AA).
偶联物
形式
Liquid
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
靶标信息
DNA methyltransferase 1-associated protein 1 (DMAP1) is involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The protein also specifically potentiates DAXX-mediated repression of glucocorticoid receptor-dependent transcription. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. DMAP1 is found in a wide variety of living organisms from yeasts to humans. The human DMAP1 gene is localized on chromosome 1p34.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: DKFZp686L09142; DNA methyltransferase 1-associated protein 1; DNMAP1; DNMT1 associated protein 1; DNMT1 associated protein-1; DNMT1-associated protein 1; FLJ11543; MAT1-mediated transcriptional repressor; RP5-891H21.2
基因别名: 1500016M21Rik; DMAP1; Dmtap1; DNMAP1; DNMTAP1; EAF2; KIAA1425; MEAF2; mKIAA1425; Mmtr; SWC4
UniProt ID: (Human) Q9NPF5, (Mouse) Q9JI44
Entrez Gene ID: (Human) 55929, (Mouse) 66233, (Rat) 298447
negative regulation of transcription from RNA polymerase II promoter
DNA repair
DNA methylation
chromatin remodeling
transcription, DNA-templated
regulation of growth
positive regulation of transcription factor import into nucleus
histone H4 acetylation
histone H2A acetylation
response to ethanol
negative regulation of transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
methylation
