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DMC1 Antibody (PA5-104492) in ICC/IF
Immunocytochemistry analysis of DMC1 in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with DMC1 polyclonal antibody (Product # PA5-104492) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
产品信息
PA5-104492
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human DMC1(Accession Q14565), corresponding to amino acid residues E67-E117.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2853793
产品详细信息
Antibody detects endogenous levels of total DMC1.
靶标信息
DMC1 is essential for meiotic homologous recombination. Genetic recombination in meiosis plays an important role in generating diversity of genetic information. The product of this protein is structurally and evolutionary related to the products of the yeast RAD51 and E. coli RecA genes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: disrupted meiotic cDNA1, yeast, homolog of; DMC 1; DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination; DMC1 homologue; HsLim15; Meiotic recombination protein DMC1/LIM15 homolog; MGC150472; MGC150473; RP1-199H16.4
基因别名: dJ199H16.1; DMC1; DMC1H; LIM15
UniProt ID: (Human) Q14565
Entrez Gene ID: (Human) 11144, (Rat) 362960
DNA recombinase assembly
ovarian follicle development
oocyte maturation
mitotic recombination
meiotic nuclear division
synapsis
reciprocal meiotic recombination
male meiosis I
spermatogenesis
spermatid development
female gamete generation
response to ionizing radiation
strand invasion
chromosome organization involved in meiotic cell cycle
DNA repair
gamete generation
