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产品信息
H00001761-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
DMRT1 (NP_068770.2, 1 a.a. approximately 373 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5-1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MPNDEAFSKP STPSEAPHAP GVPPQGRAGG FGKASGALVG AASGSSAGGS SRGGGSGSGA SDLGAGSKKS PRLPKCARCR NHGYASPLKG HKRFCMWRDC QCKKCNLIAE RQRVMAAQVA LRRQQAQEEE LGISHPIPLP SAAELLVKRE NNGSNPCLMT ECSGTSQPPP ASVPTTAASE GRMVIQDIPA VTSRGHVENT PDLVSDSTYY SSFYQPSLFP YYNNLYNCPQ YSMALAADSA SGEVGNPLGG SPVKNSLRGL PGPYVPGQTG NQWQMKNMEN RHAMSSQYRM HSYYPPPSYL GQSVPQFFTF EDAPSYPEAR ASVFSPPSSQ DSGLVSLSSS SPISNKSTKA VLECEPASEP SSFTVTPVIE EDE
靶标信息
This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DM domain expressed in testis 1; DM domain expressed in testis protein 1; Doublesex- and mab-3-related transcription factor 1
基因别名: CT154; DMRT1; DMT1
UniProt ID: (Human) Q9Y5R6
Entrez Gene ID: (Human) 1761
RNA polymerase II regulatory region sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein homodimerization activity
metal ion binding
protein heterodimerization activity
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
male germ cell proliferation
transcription from RNA polymerase II promoter
spermatogenesis
sex differentiation
germ cell migration
male sex determination
intracellular signal transduction
negative regulation of meiotic nuclear division
positive regulation of mitotic nuclear division
positive regulation of transcription from RNA polymerase II promoter
male sex differentiation
oocyte development
Sertoli cell differentiation
Sertoli cell development
positive regulation of meiosis I
regulation of nodal signaling pathway
positive regulation of male gonad development
