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产品信息
PA5-75740
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues in Human DNAJB2
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2719468
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
The DnaJ family is one of the largest of all the chaperone families and has evolved with diverse cellular localization and functions. The presence of the J domain defines a protein as a member of the DnaJ family. DnaJ heat shock induced proteins are from the bacterium Escherichia coli and are under the control of the htpR regulatory protein. The DnaJ proteins play a critical role in the HSP 70 chaperone machine by interacting with HSP 70 to stimulate ATP hydrolysis. The proteins contain cysteine rich regions that are composed of zinc fingers that form a peptide binding domain responsible for the chaperone function. DnaJ proteins are important mediators of proteolysis and are involved in the regulation of protein degradation, exocytosis and endocytosis. DnaJB2 (DnaJ homolog subfamily B member 2), also known as HSJ1 or HSPF3, is expressed almost exclusively in the brain, with the highest levels in the frontal cortex and hippocampus. Two isoforms are produced due to alternative splicing.
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生物信息学
蛋白别名: DnaJ (Hsp40) homolog, subfamily B, member 2; DnaJ homolog subfamily B member 2; dnaJ protein homolog 1; Heat shock 40 kDa protein 3; Heat shock protein J1; heat shock protein, neuronal DNAJ-like 1; HSJ-1
基因别名: CMT2T; DNAJB2; DSMA5; HSJ-1; HSJ1; HSPF3
UniProt ID: (Human) A8K9P6
Entrez Gene ID: (Human) 3300, (Rat) 689593
protein folding
response to unfolded protein
protein refolding
negative regulation of inclusion body assembly
negative regulation of cell proliferation
negative regulation of cell growth
ER-associated ubiquitin-dependent protein catabolic process
positive regulation of protein ubiquitination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of protein deubiquitination
