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产品信息
PA5-54212
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2640701
产品详细信息
Immunogen sequence: EEINEQIRKE KEEAEARMRQ ASKNTEKSTG GGGNGSKNWS EDDLQLLIKA VNLFPAGTNS RWEVIANYMN IHSSSGVKRT AKDV
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 90%.
靶标信息
EIF4EBP1 is one member of a family of translation repressor proteins. It directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: (rat homolog) mouse id-associated protein 1; DnaJ (Hsp40) homolog, subfamily C, member 2; DnaJ homolog subfamily C member 2; Gliosarcoma-related antigen MIDA1; Id associate 1; M-phase phosphoprotein 11; MIDA1; Mouse Id associate 1; zuotin related factor 1; zuotin related factor 2; Zuotin-related factor 1
基因别名: AU020218; DNAJC2; MIDA1; MPHOSPH11; MPP11; ZRF1; Zrf2; ZUO1
UniProt ID: (Human) Q99543, (Rat) Q7TQ20, (Mouse) P54103
Entrez Gene ID: (Human) 27000, (Rat) 116456, (Mouse) 22791
DNA replication
transcription, DNA-templated
covalent chromatin modification
negative regulation of cell growth
positive regulation of ATPase activity
positive regulation of transcription, DNA-templated
'de novo' cotranslational protein folding
regulation of cellular response to heat
negative regulation of DNA biosynthetic process
chromatin modification
regulation of transcription, DNA-templated
