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Product Details
PA5-54212
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DNAJC2. Recombinant protein control fragment (Product #RP-92635).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2640701
Product Specific Information
Immunogen sequence: EEINEQIRKE KEEAEARMRQ ASKNTEKSTG GGGNGSKNWS EDDLQLLIKA VNLFPAGTNS RWEVIANYMN IHSSSGVKRT AKDV
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 90%.
Target Information
EIF4EBP1 is one member of a family of translation repressor proteins. It directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: (rat homolog) mouse id-associated protein 1; DnaJ (Hsp40) homolog, subfamily C, member 2; DnaJ homolog subfamily C member 2; Gliosarcoma-related antigen MIDA1; Id associate 1; M-phase phosphoprotein 11; MIDA1; Mouse Id associate 1; zuotin related factor 1; zuotin related factor 2; Zuotin-related factor 1
Gene Aliases: AU020218; DNAJC2; MIDA1; MPHOSPH11; MPP11; ZRF1; Zrf2; ZUO1
UniProt ID: (Human) Q99543, (Rat) Q7TQ20, (Mouse) P54103
Entrez Gene ID: (Human) 27000, (Rat) 116456, (Mouse) 22791
DNA replication
transcription, DNA-templated
covalent chromatin modification
negative regulation of cell growth
positive regulation of ATPase activity
positive regulation of transcription, DNA-templated
'de novo' cotranslational protein folding
regulation of cellular response to heat
negative regulation of DNA biosynthetic process
chromatin modification
regulation of transcription, DNA-templated
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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