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DOCK1 Antibody (PA5-101550) in IHC (P)
Immunohistochemistry analysis of DOCK1 in human colorectal cancer and adjacent normal tissues. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with DOCK1 polyclonal antibody (Product # PA5-101550) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-101550
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human DOCK1(Accession Q14185), corresponding to amino acid residues R1661-E1711.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2850984
产品详细信息
Antibody detects endogenous levels of total DOCK1.
靶标信息
This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 180 kDa protein downstream of CRK; dedicator of cyto-kinesis 1; Dedicator of cytokinesis protein 1; dock 180; DOCK180; DOwnstream of CrK; RP11-82L9.1
基因别名: 9130006G06Rik; AI854900; ced5; D630004B07Rik; DOCK1; DOCK180; RGD1566072
UniProt ID: (Human) Q14185, (Mouse) Q8BUR4
Entrez Gene ID: (Human) 1793, (Mouse) 330662, (Rat) 309081
phagocytosis, engulfment
apoptotic process
cytoskeleton organization
signal transduction
integrin-mediated signaling pathway
small GTPase mediated signal transduction
blood coagulation
positive regulation of epithelial cell migration
cell migration
Fc-gamma receptor signaling pathway involved in phagocytosis
positive regulation of GTPase activity
vascular endothelial growth factor receptor signaling pathway
positive regulation of substrate adhesion-dependent cell spreading
hematopoietic progenitor cell differentiation
phagocytosis
