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产品信息
PA5-63767
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human DOCK11. Recombinant protein control fragment (Product #RP-101934).
偶联物
形式
Liquid
浓度
0.05 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2640736
产品详细信息
Immunogen sequence: KDTVETAQDD ETSSQGKAEN IMASLERSMH PELMKYGRET EQLNKLSRGD GRQNLFSFDS EVQRLDFSGI EPDIKPFEEK CNKRFLVNCH DLTF
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.
靶标信息
Small GTPases of the Rho family, Rho, Rac, and Cdc42, are critical regulators of the actin cytoskeleton and many other cellular processes. Rho GTPases are activated by Dbl-homology (DH)-domain-containing guanine nucleotide exchange factors (GEFs). DOCK 11 (dedicator of cytokinesis 11), also known as ACG or ZIZ2 (zizimin2), is a 2073 amino acid protein belonging to the DOCK family of cytokinesis-regulating proteins that is mainly expressed in peripheral blood leukocytes. DOCK 11 functions as a GEF that binds and activates Cdc42 by exchanging bound GDP for free GTP. Cdc42 mediates cell polarity, gene expression, cell cycle progression and cell-cell contacts. Similar to other DOCK family members, DOCK 11 contains a PH domain and two internal DOCK homology regions designated DHR1 and DHR2.
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生物信息学
蛋白别名: ACG; Activated Cdc42-associated guanine nucleotide exchange factor; Activated Cdc42-associated guanine nucleotide exchange factor, ACG; bB128O4.1.1 (novel protein); Dedicator of cytokinesis protein 11; DOCK-11; Zizimin 2; Zizimin-2; zizimin2
基因别名: ACG; bB128O4.1; DOCK11; ZIZ2
UniProt ID: (Human) Q5JSL3
Entrez Gene ID: (Human) 139818
