Invitrogen

DP1 Polyclonal Antibody

DP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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DP1 Antibody (PA5-81276) in IHC (P)

Immunohistochemical staining of human DP1 in human breast carcinoma with DP1 Polyclonal Antibody (Product # PA5-81276, 1:1,000, formalin-fixed paraffin embedded sections).

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产品信息

PA5-81276

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1:500-1:2,000

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide corresponding to the C-terminus of the Human TFDP1

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A, Antigen affinity chromatography

保存液

PBS

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2788497

产品详细信息

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).

This antibody has specificity for Human DP1.

靶标信息

DP family contains at least two members, DP1 and 2. Structurally, DP1 and 2 are relatively conserved, yet their expression appears to be tissue specific. E2F 1, a functional target for the tumor suppressor protein Rb, heterodimerizes with DP1 and forms an active E2F transcriptional complex. The interaction between members of the E2F and the DP families is mediated, in part, by a leucine repeat which is weakly conserved between the two families.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: AS1; ASRT1; down-regulated in liver cancer stem cells; DP; DRTF1; DRTF1-polypeptide 1; E2F dimerization partner 1; E2F-related transcription factor; MGC49004; OTTHUMP00000018767; Transcription factor Dp-1

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基因别名: DILC; Dp-1; DP1; DRTF1; TFDP1

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UniProt ID: (Human) Q14186

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Entrez Gene ID: (Human) 7027

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功能

RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding transcription factor binding protein domain specific binding DNA-binding transcription factor

参与通路

transcription, DNA-templated regulation of transcription from RNA polymerase II promoter DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest cell proliferation positive regulation of transcription from RNA polymerase II promoter negative regulation of fat cell proliferation positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway