Invitrogen

DPP4 Recombinant Rabbit Monoclonal Antibody (007), FITC

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DPP4 Antibody (MA5-52419) in Flow

Flow cytometry analysis of Mouse DPP4(CD26) expression on BABL/c splenocytes. Samples were incubated with DPP4 monoclonal antibody (Product # MA5-52419). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

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产品信息

MA5-52419

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

5 µL per test

产品规格

种属反应

Mouse

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

007

抗原

Recombinant Mouse DPP4/CD26 Protein (Ser29-His760)

查看免疫原

偶联物

FITC FITC FITC

激发/发射光谱

498/517 nm 查看光谱

形式

Liquid

浓度

100 µg/mL

纯化类型

Protein A

保存液

PBS with 0.5% BSA

内含物

0.03% ProClin 300

保存条件

4° C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

CD26 (dipeptidyl peptidase IV, DPP IV), adenosine deaminase (ADA) binding protein) is a homodimeric atypical serine protease belonging to the prolyl oligopeptidase family. CD26 is expressed on lymphocyte cells and is upregulated during T-cell activation. CD26 is also expressed on activated B cells and natural killer cells and abundantly on epithelia. CD26 is implicated in a variety of biological functions including T-cell activation, cell adhesion with extracellular matrix such as fibronectin or collagens, and in HIV infection. CD26 identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. Further, CD26 is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Alterations in CD26 peptidase activity are characteristic of malignant transformation, and the enzymatic activity increases dramatically with tumor grade and severity. CD26 is expressed in various blood cell types, but also in cells that are histogenetically related to activated fibroblasts. Alterations in CD26 density have been reported on circulating monocytes and CD4+ T cells during rheumatoid arthritis and systemic lupus erythematosus.

仅用于科研。不用于诊断过程。未经明确授权不得转售。