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Product Details
PA5-79170
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Dopamine Receptor D3 (352-367aa NTHCQTCHVSPELYSA).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2746286
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: Rat Testis Tissue, Rat Brain Tissue, U87 Cell, HELA Cell. IHC: Rat Brain Tissue.
Target Information
This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: D(3) dopamine receptor; D3 receptor; D3nf; Dopamine 3 receptor; Dopamine D3 receptor; dopamine receptor 3; dopaminergic receptor D3; essential tremor 1
Gene Aliases: D3DR; D3R; DRD3; ETM1; FET1
UniProt ID: (Human) P35462, (Rat) P19020, (Mouse) P30728
Entrez Gene ID: (Human) 1814, (Rat) 29238, (Mouse) 13490
dopamine neurotransmitter receptor activity, coupled via Gs
dopamine neurotransmitter receptor activity, coupled via Gi/Go
protein binding
drug binding
protein domain specific binding
D1 dopamine receptor binding
dopamine binding
dopamine neurotransmitter receptor activity
signal transducer activity
G-protein coupled receptor activity
G-protein coupled amine receptor activity
negative regulation of transcription from RNA polymerase II promoter
synaptic transmission, dopaminergic
response to amphetamine
regulation of blood volume by renin-angiotensin
G-protein coupled receptor internalization
cellular calcium ion homeostasis
G-protein coupled receptor signaling pathway
adenylate cyclase-activating dopamine receptor signaling pathway
negative regulation of adenylate cyclase activity
adenylate cyclase-inhibiting dopamine receptor signaling pathway
learning or memory
learning
locomotory behavior
positive regulation of cell proliferation
visual learning
regulation of dopamine secretion
regulation of lipid metabolic process
regulation of cAMP metabolic process
negative regulation of sodium:proton antiporter activity
positive regulation of cytokinesis
circadian regulation of gene expression
response to histamine
social behavior
gastric emptying
positive regulation of renal sodium excretion
regulation of multicellular organism growth
response to cocaine
dopamine metabolic process
response to drug
response to morphine
regulation of circadian sleep/wake cycle, sleep
response to ethanol
negative regulation of blood pressure
positive regulation of mitotic nuclear division
positive regulation of transcription from RNA polymerase II promoter
acid secretion
behavioral response to cocaine
negative regulation of oligodendrocyte differentiation
arachidonic acid secretion
negative regulation of protein secretion
musculoskeletal movement, spinal reflex action
regulation of dopamine uptake involved in synaptic transmission
negative regulation of protein kinase B signaling
prepulse inhibition
negative regulation of dopamine receptor signaling pathway
positive regulation of dopamine receptor signaling pathway
regulation of locomotion involved in locomotory behavior
dopamine receptor signaling pathway
chemical synaptic transmission
regulation of locomotion
signal transduction
sensory perception of chemical stimulus
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