Invitrogen

DTYMK Polyclonal Antibody

DTYMK Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 3

DTYMK Antibody (PA5-120995) in ICC/IF

Immunofluorescence analysis of DTYMK in U-2 OS cells. Samples were incubated with DTYMK Polyclonal antibody (Product # PA5-120995) using a dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

Product Image Gallery

产品信息

PA5-120995

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

免疫细胞化学 (ICC/IF)

1:50-1:200

酶联免疫吸附实验 (ELISA)

1 µg/mL

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 1-212 of human DTYMK (NP_036277.2).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

2.37 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2914567

产品详细信息

Positive test controls include: 22Rv1, HeLa, HepG2, Raji, MCF7, Mouse bone marrow, Mouse spleen, Rat testis.

Immunogen sequence: MAARRGALIV LEGVDRAGKS TQSRKLVEAL CAAGHRAELL RFPERSTEIG KLLSSYLQKK SDVEDHSVHL LFSANRWEQV PLIKEKLSQG VTLVVDRYAF SGVAFTGAKE NFSLDWCKQP DVGLPKPDLV LFLQLQLADA AKRGAFGHER YENGAFQERA LRCFHQLMKD TTLNWKMVDA SKSIEAVHED IRVLSEDAIR TATEKPLGEL WK

靶标信息

Thymidylate kinase (DTYMK) catalyzes the phosphorylation of dTMP to form dTDP in the dTTP synthesis pathway for DNA synthesis. DTYMK is essential for DNA synthesis and is an important intermediate enzyme in the pathway of many pyrimidine analog drugs, including 5-Fluorouracil (5-FU), the chemotherapeutic drug of choice for several solid tumors. The human DTYMK gene was isolated via functional complementation of a Saccharomyces cerevisiae cell cycle mutant, cdc8. DTYMK mRNA levels and enzyme activities are regulated at the level of cell cycle and cell growth pathways.

仅用于科研。不用于诊断过程。未经明确授权不得转售。