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产品信息
PA5-30010
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 1 and 207 of Human Thymidylate kinase
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2547484
产品详细信息
Recommended positive controls: Raji.
Predicted reactivity: Mouse (81%), Rat (81%), Bovine (83%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Thymidylate kinase (DTYMK) catalyzes the phosphorylation of dTMP to form dTDP in the dTTP synthesis pathway for DNA synthesis. DTYMK is essential for DNA synthesis and is an important intermediate enzyme in the pathway of many pyrimidine analog drugs, including 5-Fluorouracil (5-FU), the chemotherapeutic drug of choice for several solid tumors. The human DTYMK gene was isolated via functional complementation of a Saccharomyces cerevisiae cell cycle mutant, cdc8. DTYMK mRNA levels and enzyme activities are regulated at the level of cell cycle and cell growth pathways.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: deoxythymidylate kinase (thymidylate kinase); dTMP kinase; Thymidylate kinase
基因别名: CDC8; DTYMK; PP3731; TMPK; TYMK
UniProt ID: (Human) P23919
Entrez Gene ID: (Human) 1841
dUDP biosynthetic process
dTDP biosynthetic process
dTTP biosynthetic process
cell cycle
cell proliferation
nucleobase-containing small molecule interconversion
response to estrogen
myoblast differentiation
response to cadmium ion
nucleotide phosphorylation
nucleoside monophosphate phosphorylation
cellular response to growth factor stimulus
