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产品信息
PA5-77036
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant full length Human DTYMK.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2720763
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
Thymidylate kinase (DTYMK) catalyzes the phosphorylation of dTMP to form dTDP in the dTTP synthesis pathway for DNA synthesis. DTYMK is essential for DNA synthesis and is an important intermediate enzyme in the pathway of many pyrimidine analog drugs, including 5-Fluorouracil (5-FU), the chemotherapeutic drug of choice for several solid tumors. The human DTYMK gene was isolated via functional complementation of a Saccharomyces cerevisiae cell cycle mutant, cdc8. DTYMK mRNA levels and enzyme activities are regulated at the level of cell cycle and cell growth pathways.
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生物信息学
蛋白别名: deoxythymidylate kinase (thymidylate kinase); dTMP kinase; Thymidylate kinase
基因别名: AU044245; CDC8; D10Ertd203e; DTYMK; mtmk; PP3731; Tmk; TMPK; TYMK; TYPK
UniProt ID: (Human) P23919, (Mouse) P97930
Entrez Gene ID: (Human) 1841, (Mouse) 21915, (Rat) 301622
dUDP biosynthetic process
dTDP biosynthetic process
dTTP biosynthetic process
cell cycle
cell proliferation
nucleobase-containing small molecule interconversion
response to estrogen
myoblast differentiation
response to cadmium ion
nucleotide phosphorylation
nucleoside monophosphate phosphorylation
cellular response to growth factor stimulus
nucleotide biosynthetic process
phosphorylation
