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产品信息
PA5-109668
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DUSP8 (NP_0044112)
偶联物
形式
Liquid
浓度
0.97 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2855079
产品详细信息
Immunogen sequence: NleAGDRLPR KVNl
靶标信息
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Dual specificity protein phosphatase 8; Dual specificity protein phosphatase hVH-5; FLJ42476; FLJ42958; H1 phosphatase, vaccinia virus homolog; Neuronal tyrosine threonine phosphatase 1; neuronal tyrosine/threonine phosphatase 1; OTTHUMP00000164487; serine/threonine specific protein phosphatase
基因别名: 5530400B01Rik; AI593498; C11orf81; DUSP8; HB5; HVH-5; HVH8; M3/6; Nttp1; VH5
UniProt ID: (Human) Q13202, (Mouse) O09112
Entrez Gene ID: (Human) 1850, (Rat) 361679, (Mouse) 18218
