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DUT Antibody (PA5-76784) in IHC (P)
Immunohistochemistry analysis of DUT in paraffin-embedded human liver cancer. Samples were incubated with DUT polyclonal antibody (Product # PA5-76784) using a dilution of 1:100. Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-76784
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant full length Human DUT.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2720511
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Deoxyuridine 5'-triphosphate nucleotidohydrolase; Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial; dUTP diphosphatase; dUTP nucleotidohydrolase; dUTP pyrophosphatase; dUTPase; FLJ20622; PIP4; PPAR-interacting protein 4
基因别名: 5031412I06Rik; 5133400F09Rik; D2Bwg0749e; DUT; Dutp; dUTPase; PIP4
UniProt ID: (Human) P33316, (Rat) P70583, (Mouse) Q9CQ43
Entrez Gene ID: (Human) 1854, (Rat) 497778, (Mouse) 110074
nucleobase-containing compound metabolic process
dUMP biosynthetic process
DNA replication
dUTP catabolic process
pyrimidine nucleoside biosynthetic process
liver development
response to organic cyclic compound
regulation of protein heterodimerization activity
protein homotrimerization
negative regulation of receptor activity
