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产品信息
PA5-142878
产品规格
种属反应
Human,
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence C-PQLEEAPLTVKSD.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2933521
产品详细信息
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000.
靶标信息
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cellproliferation, acting as a transducer molecule for developmentalprocesses, including segmentation and neuroblast specification.DVL1 is a candidate gene for neuroblastomatous transformation. TheSchwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2Ahave been mapped to the same region as DVL1. The phenotypes ofthese diseases may be consistent with defects which might beexpected from aberrant expression of a DVL gene during development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: dishevelled 1 (homologous to Drosophila dsh); dishevelled, dsh homolog 1; Dishevelled-1; Dishevelled-1-like; DSH homolog 1; DSH homolog 1-like; MGC54245; RP5-890O3.5; Segment polarity protein dishevelled homolog DVL-1
基因别名: DRS2; DVL; DVL1; DVL1L1; DVL1P1; mKIAA4029
UniProt ID: (Human) O14640, (Mouse) P51141
Entrez Gene ID: (Human) 1855, (Mouse) 13542
regulation of neurotransmitter levels
positive regulation of protein phosphorylation
transcription from RNA polymerase II promoter
negative regulation of protein kinase activity
neurotransmitter secretion
axon guidance
synapse assembly
heart development
neuromuscular junction development
positive regulation of neuron projection development
neural tube development
convergent extension involved in neural plate elongation
positive regulation of Wnt signaling pathway
cytoplasmic microtubule organization
negative regulation of protein binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
protein localization to nucleus
social behavior
protein localization to microtubule
intracellular signal transduction
receptor clustering
positive regulation of transcription, DNA-templated
collateral sprouting
axon extension
dendrite morphogenesis
synapse organization
protein stabilization
canonical Wnt signaling pathway
Wnt signaling pathway, planar cell polarity pathway
prepulse inhibition
skeletal muscle acetylcholine-gated channel clustering
negative regulation of canonical Wnt signaling pathway
cochlea morphogenesis
planar cell polarity pathway involved in neural tube closure
positive regulation of canonical Wnt signaling pathway
positive regulation of protein localization to synapse
regulation of cellular protein localization
beta-catenin destruction complex disassembly
