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产品信息
PA5-40486
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the N-terminal of human DVL2 (aa 2-51).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2610456
产品详细信息
Peptide sequence: AGSSTGGGGV GETKVIYHLD EEETPYLVKI PVPAERITLG DFKSVLQRPA
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 82%; Zebrafish: 93%
靶标信息
Disheveled DVL2 is a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: dishevelled 2 (homologous to Drosophila dsh); dishevelled, dsh homolog 2; Dishevelled-2; DSH homolog 2; Segment polarity protein dishevelled homolog DVL-2
基因别名: DVL2
UniProt ID: (Human) O14641
Entrez Gene ID: (Human) 1856
neural tube closure
positive regulation of protein phosphorylation
outflow tract morphogenesis
transcription from RNA polymerase II promoter
segment specification
heart development
Wnt signaling pathway
convergent extension involved in neural plate elongation
cellular protein localization
hippo signaling
non-canonical Wnt signaling pathway
positive regulation of JUN kinase activity
positive regulation of GTPase activity
canonical Wnt signaling pathway involved in regulation of cell proliferation
positive regulation of transcription, DNA-templated
positive regulation of sequence-specific DNA binding transcription factor activity
protein oligomerization
canonical Wnt signaling pathway
Wnt signaling pathway, planar cell polarity pathway
positive regulation of protein tyrosine kinase activity
negative regulation of canonical Wnt signaling pathway
cochlea morphogenesis
planar cell polarity pathway involved in neural tube closure
positive regulation of canonical Wnt signaling pathway
beta-catenin destruction complex disassembly
