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DYNLT1 Antibody (PA5-79177) in IHC (P)
Immunohistochemistry analysis of DYNLT1 on paraffin-embedded human colon cancer tissue. Antigen retrieval was performed using citrate buffer (pH6, epitope retrieval solution) for 20 mins. Sample was blocked using 10% goat serum, incubated with DYNLT1 polyclonal antibody (Product# PA5-79177) with a dilution of 1 µg/mL (overnight at 4°C), and followed by biotinylated goat anti-rabbit IgG (30 minutes at 37°C).... View More
产品信息
PA5-79177
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived human DYNLT1 recombinant protein (Position: M1-A80).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2746293
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. May also be a accessory component of axonemal dynein. Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Activator of G-protein signaling 2; AGS2; Dynein light chain Tctex-type 1; dynein light chain Tctex-type 1D; dynein, light chain, Tctex-type 1; Protein CW-1; t-complex testis expressed 1; T-complex testis-specific protein 1; T-complex testis-specific protein 1 homolog; t-complex-associated-testis-expressed 1-like 1; TCTEX-1
基因别名: AGS2; CW-1; DYNLT1; TCTEL1; TCTEX-1; TCTEX1
UniProt ID: (Human) P63172, (Rat) Q9Z336, (Mouse) P51807
Entrez Gene ID: (Human) 6993, (Rat) 83462, (Mouse) 21648
establishment of mitotic spindle orientation
mitotic nuclear division
regulation of G-protein coupled receptor protein signaling pathway
intracellular transport of viral protein in host cell
regulation of GTPase activity
viral entry into host cell
neuron projection morphogenesis
negative regulation of neurogenesis
cell division
regulation of cytoskeleton organization
microtubule-dependent intracellular transport of viral material towards nucleus
intracellular protein transport
microtubule-based process
metabolic process
