Invitrogen

Decorin Polyclonal Antibody

Decorin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Decorin Antibody (PA5-13538) in IHC (P)

Immunohistochemistry analysis of Decorin in formalin-fixed and paraffin-embedded human hepatocarcinoma. Samples were incubated with Decorin polyclonal antibody (Product # PA5-13538) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Decorin Antibody in Flow Cytometry (Flow)

Decorin Antibody in Immunohistochemistry (IHC)

Decorin Antibody in Western Blot, Immunoprecipitation (WB, IP)

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产品信息

PA5-13538

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:10-1:50

流式细胞分析 (Flow)

1:10-1:50

免疫沉淀 (IP)

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产品规格

种属反应

Human, Mouse

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide between 122-150 amino acids from the central region of human DCN

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

2 mg/mL

纯化类型

Size-exclusion - Dialysis, Ammonium sulfate precipitation

保存液

PBS, pH 7.4

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2090260

产品详细信息

This antibody is predicted to react with bovine and porcine based on sequence homology.

靶标信息

Decorin is a member of the small, leucine-rich proteoglycan (SLRP) family along with biglycan. Found in the interterritorial region of cartilage, decorin interacts with collagen and other matrix proteins to regulate the cartilaginous matrix. It has been shown to interact with fibronectin, thrombospondin, C1q, epidermal growth factor receptor (EGFR), and TGF-b. It is believed that decorin also plays a role in the cell cycle of chondrocytes. The decorin neoepitope fragment has a sequence of PKTLQE, and is generated by MMP-3 or ADAMTS-4 cleavage at Glu154-Leu155 of decorin core protein.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

DCN released from ferroptotic cells ignites AGER-dependent immune responses.

Autophagy

Liu J,Zhu S,Zeng L,Li J,Klionsky DJ,Kroemer G,Jiang J,Tang D,Kang R

PA5-13538 was used in Western Blotting to report that the proteoglycan decorin (DCN) is released by cells that are dying from ferroptosis and then acts as an alarm signal to trigger innate and adaptive immune responses.

Thu Sep 01 00:00:00 UTC 2022

DCN released from ferroptotic cells ignites AGER-dependent immune responses.

Autophagy

Liu J,Zhu S,Zeng L,Li J,Klionsky DJ,Kroemer G,Jiang J,Tang D,Kang R

Thu Sep 01 00:00:00 UTC 2022

Obesity reduces mammary epithelial cell TGFβ1 activity through macrophage-mediated extracellular matrix remodeling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Chamberlin T,Thompson V,Hillers-Ziemer LE,Walton BN,Arendt LM

PA5-13538 was used in Western Blotting to show TGFβ1 activity is reduced in the breast epithelial cells in obesity.

Mon Jun 01 00:00:00 UTC 2020

Obesity reduces mammary epithelial cell TGFβ1 activity through macrophage-mediated extracellular matrix remodeling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Chamberlin T,Thompson V,Hillers-Ziemer LE,Walton BN,Arendt LM

PA5-13538 was used in Western Blotting to show TGFβ1 activity is reduced in the breast epithelial cells in obesity.

Mon Jun 01 00:00:00 UTC 2020

Obesity reduces mammary epithelial cell TGFβ1 activity through macrophage-mediated extracellular matrix remodeling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Chamberlin T,Thompson V,Hillers-Ziemer LE,Walton BN,Arendt LM

PA5-13538 was used in Western Blotting to show TGFβ1 activity is reduced in the breast epithelial cells in obesity.

Mon Jun 01 00:00:00 UTC 2020

Cadherin-6 type 2, K-cadherin (CDH6) is regulated by mutant p53 in the fallopian tube but is not expressed in the ovarian surface.

Oncotarget

Karthikeyan S,Lantvit DD,Chae DH,Burdette JE

PA513538 was used in immunohistochemistry - paraffin section and western blot to find that CDH6 is expressed in the oviduct and is repressed by mutant p53

Tue Oct 25 00:00:00 UTC 2016

Cadherin-6 type 2, K-cadherin (CDH6) is regulated by mutant p53 in the fallopian tube but is not expressed in the ovarian surface.

Oncotarget

Karthikeyan S,Lantvit DD,Chae DH,Burdette JE

PA513538 was used in immunohistochemistry - paraffin section and western blot to find that CDH6 is expressed in the oviduct and is repressed by mutant p53

Tue Oct 25 00:00:00 UTC 2016

生物信息学

蛋白别名: Bone proteoglycan II; Decorin; dermatan sulphate proteoglycans II; Dermatan sulphate proteoglycans II (DSPG2); PG-S2; PG40; proteoglycan core protein; Small leucine rich protein 1B; small leucine-rich protein 1B

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基因别名: CSCD; DC; DCN; DSPG2; mDcn; PG40; PGII; PGS2; SLRR1B

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UniProt ID: (Human) P07585, (Mouse) P28654

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Entrez Gene ID: (Human) 1634, (Mouse) 13179

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功能

protein kinase inhibitor activity protein binding collagen binding glycosaminoglycan binding poly(A) RNA binding protein N-terminus binding extracellular matrix binding

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