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Invitrogen
Dectin 1 (soluble) Recombinant Rabbit Monoclonal Antibody (010)
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Dectin 1 (soluble) Antibody (MA5-29688) in ICC/IF
Immunofluorescence staining of mouse Dectin-1 in Raw264.7 cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with Dectin 1 (soluble) Recombinant Rabbit Monoclonal Antibody (10) (Product # MA5-29688, 1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue).
产品信息
MA5-29688
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
010
抗原
Recombinant Mouse Dectin-1/CLEC7A protein (Phe69-Leu244)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2785512
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Mouse Dectin-1/CLEC7A.
靶标信息
CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: beta-glucan receptor; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12; C-type lectin domain family 7 member A; C-type lectin superfamily member 12; DC-associated C-type lectin 1; dectin-1; dendritic cell-associated C-type lectin 1
基因别名: beta-GR; BGR; Clecsf12
Entrez Gene ID: (Mouse) 56644
response to yeast
detection of yeast
pattern recognition receptor signaling pathway
response to molecule of fungal origin
leukocyte activation involved in immune response
immune system process
cell surface pattern recognition receptor signaling pathway
phagocytosis, recognition
phagocytosis, engulfment
inflammatory response
cell recognition
single organismal cell-cell adhesion
positive regulation of tumor necrosis factor production
innate immune response
positive regulation of phagocytosis
cellular response to molecule of fungal origin
