Invitrogen

Dematin Polyclonal Antibody

Dematin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Dematin Antibody (PA5-140094) in IHC (P)

Immunohistochemical analysis of Dematin in human cerebral cortex using Dematin Polyclonal Antibody (Product # PA5-140094) shows weak cytoplasmic positivity in neuronal cells.

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产品信息

PA5-140094

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1:5,000-1:10,000

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human DMTN. Recombinant protein control fragment (Product #RP-108960).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.3 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2927096

产品详细信息

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.

Immunogen sequence: DDDSGEEMKA LRERQREELS KVTSNLGKMI LKEEMEKSLP IRRKTRSLPD RTPFHTSLHQ GT

靶标信息

The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms.

仅用于科研。不用于诊断过程。未经明确授权不得转售。