Invitrogen

Desmin Polyclonal Antibody

Desmin Antibody in Immunocytochemistry (ICC/IF)

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Desmin Antibody (PA5-119736) in ICC/IF

Immunocytochemistry-Immunofluorescence analysis of of Desmin in NIH-3T3 cells (green) using Desmin Polyclonal Antibody (Product # PA5-119736). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Desmin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

PA5-119736

应用

建议稀释比

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免疫印迹 (WB)

1:1,000-1:2,000

免疫组化（石蜡） (IHC (P))

1:200

免疫细胞化学 (ICC/IF)

1:200

产品规格

种属反应

Human, Mouse, Rat, Zebrafish

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein within human desmin aa 405-470

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 40% glycerol, 0.2% BSA

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2913308

产品详细信息

Positive Control: Human heart tissue, human skeletal muscle tissue, mouse heart tissue, human uterus tissue, mouse skeletal muscle tissue, HepG2,NIH-3T3,Hela

Subcellular Location: Cytoplasm

靶标信息

Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.

仅用于科研。不用于诊断过程。未经明确授权不得转售。