Invitrogen

Desmin Monoclonal Antibody (D9)

Desmin Antibody in Immunohistochemistry (Frozen) (IHC (F))

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Desmin Antibody (MA1-06401) in IHC (F)

Immunohistochemistry on frozen sections of swine stomach showing staining of muscle tissues stained with Desmin monoclonal antibody (Product # MA1-06401).

Desmin Antibody in Immunohistochemistry (IHC)

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产品信息

MA1-06401

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:100-1:1,000

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:25-1:200

免疫组化（冰冻） (IHC (F))

1:25-1:200

其他PubMed (MISC)

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产品规格

种属反应

Chicken, Human, Mouse, Pig, Rabbit, Rat

已发表种属

Human, Pig, Rat, Rhesus monkey

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

抗原

Desmin isolated from human leiomyoma.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

purified

保存液

PBS

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_558631

产品详细信息

MA1-06401 detects desmin in human, mouse, rat, rabbits, pig, and chicken samples.

MA1-06401 has sucessfully been used in Western blotting, and immunohistochemistry. By Western blotting, it detects a ~53 kDa protein representing desmin.

The MA1-06401 immunogen is desmin isolated from human leiomyoma.

靶标信息

Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Tumor microenvironment in a minipig model of spinal cord glioma.

Journal of translational medicine

Tora MS,Neill SG,Lakhina Y,Assed H,Zhang M,Nagarajan PP,Federici T,Gutierrez J,Hoang KB,Du Y,Lei K,Boulis NM

MA1-06401 was used in Immunohistochemistry to support the utility of a high-grade spinal cord glioma (SCG) model in Göttingen minipigs as a means for investigating therapeutic approaches targeting the more aggressive and surgically unresectable tumor border.

Wed Sep 27 00:00:00 UTC 2023

Multiple benign fibrous histiocytomas of the mandible: A case report and review of the literature.

Experimental and therapeutic medicine

Wang Y,Huang Y,Cai WX,Tao Q

MA1-06401 was used in Immunohistochemistry to suggest that BFH has a risk of recurrence after transoral curettage. Regular follow-up is advised to detect tumor recurrence after the surgery of transoral curettage.

Thu Sep 01 00:00:00 UTC 2022

Multiple benign fibrous histiocytomas of the mandible: A case report and review of the literature.

Experimental and therapeutic medicine

Wang Y,Huang Y,Cai WX,Tao Q

Thu Sep 01 00:00:00 UTC 2022

The RNA-binding protein HuR is a negative regulator in adipogenesis.

Nature communications

Siang DTC,Lim YC,Kyaw AMM,Win KN,Chia SY,Degirmenci U,Hu X,Tan BC,Walet ACE,Sun L,Xu D

Published figure using Desmin monoclonal antibody (Product # MA1-06401) in Western Blot

Fri Jan 10 00:00:00 UTC 2020

Spontaneous Urinary Bladder Leiomyoma in a Rhesus Macaque (Macaca mulatta).

Comparative medicine

Scott KE,Frydman G,Fox JG,Bakthavatchalu V

MA1-06401 was used in Immunohistochemistry to report the case of a urinary bladder leiomyoma in a rhesus macaque.

Fri Jun 01 00:00:00 UTC 2018

Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle.

Endocrinology

Lesmana R,Sinha RA,Singh BK,Zhou J,Ohba K,Wu Y,Yau WW,Bay BH,Yen PM

MA1-06401 was used in western blot to investigate thyroid hormone-mediated autophagy in skeletal muscle

Fri Jan 01 00:00:00 UTC 2016

生物信息学

蛋白别名: CMD1I; Desmin; FLJ12025; FLJ39719; FLJ41013; FLJ41793; intermediate filament protein; MFM1; muscle-specific intermediate filament desmin; mutant desmin p.K241E; SCPNK

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基因别名: CSM1; CSM2; DES; LGMD2R