NeoBiotechnologies

Desmin (Muscle Cell Marker) Recombinant Mouse Monoclonal Antibody (rDES/1711)

Desmin (Muscle Cell Marker) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Desmin (Muscle Cell Marker) Antibody (1674-MSM4-P1) in IHC (P)

IHC analysis of formalin-fixed, paraffin-embedded human uterus. stained using rDES/1711 at 2 µg/mL in PBS for 30 min RT. HIER: Tris/EDTA, pH9.0, 45 min. 2nd Ab: HRP-polymer, 30 min. DAB, 5 min.

Desmin (Muscle Cell Marker) Antibody in Immunoelectrophoresis (IE)

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产品信息

1674-MSM4-P1

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1-2 µg/mL

免疫电泳 (IE)

Assay-dependent

产品规格

种属反应

Chicken, Hamster, Human, Mouse, Rat

宿主/亚型

Mouse / IgG1, kappa

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

rDES/1711

抗原

Recombinant full-length human desmin protein

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

Protein A/G

保存液

PBS with 0.05% BSA

内含物

0.05% sodium azide

保存条件

4° C

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Antibody is stable for 24 months.

Positive Control: SJRH30 cells.Uterus or Leiomyosarcoma. Cellular Localization: Cytoplasm

Specificity Comments: Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain -helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles.Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

靶标信息

Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: CMD1I; Desmin; desmin-like protein; FLJ12025; FLJ39719; FLJ41013; FLJ41793; intermediate filament protein; MFM1; mutant desmin p.K241E; SCPNK

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基因别名: CSM1; CSM2; DES; I79_018932; LGMD2R

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UniProt ID: (Human) P17661, (Rat) P48675, (Mouse) P31001