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产品信息
1824-MSM1-P1ABX
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
7G6
抗原
Human desmocollin-2 extracellular domain
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ARVC10; ARVD10; Cadherin family member 2; Cadherin family member 3; CDHF5; CDHF6; CMD1BB; Desmocollin-2; Desmocollin-3; Desmocollin-4; desmoglein-2; desmoglein-3; Desmosomal glycoprotein II; desmosomal glycoprotein II/III; Desmosomal glycoprotein III; Epithelial type 2 desmocollin; HDGC; HT-CP; PVA
基因别名: 5430426I24Rik; ARVD11; AW228162; CDHF2; CDHF3; DG2; DGII/III; DSC; DSC1; DSC2; Dsc2a; Dsc2b; DSC3; DSC4; HT-CP
UniProt ID: (Human) Q02487, (Human) Q14574, (Mouse) P55292, (Mouse) P55850
Entrez Gene ID: (Human) 1824, (Human) 1825, (Rat) 291760, (Mouse) 13506, (Mouse) 13507, (Rat) 307563
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
cellular response to starvation
cardiac muscle cell-cardiac muscle cell adhesion
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
regulation of heart rate by cardiac conduction
regulation of ventricular cardiac muscle cell action potential
ventricular cardiac muscle cell action potential
bundle of His cell to Purkinje myocyte communication
in utero embryonic development
protein stabilization
