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产品信息
PA1-4654
产品规格
种属反应
Human,
Mouse,
Non-human primate
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to the C-terminal region of human DBH conjugated to KLH
偶联物
形式
Liquid
纯化类型
Affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2089363
产品详细信息
This antibody is specific for the ~75 kDa DBH protein in Western blots of human adrenal medulla. It also recognizes DBH in monkey and mouse tissues.
靶标信息
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Dopamine beta-hydroxylase; dopamine beta-hydroxylase (dopamine beta-monooxygenase); Dopamine beta-monooxygenase; Dopamine-Beta-hydroxylase; Soluble dopamine beta-hydroxylase
基因别名: DBH; DBM
UniProt ID: (Human) P09172, (Mouse) Q64237
Entrez Gene ID: (Human) 1621, (Mouse) 13166
catalytic activity
dopamine beta-monooxygenase activity
copper ion binding
L-ascorbic acid binding
monooxygenase activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
metal ion binding
cytokine production
blood vessel remodeling
response to amphetamine
leukocyte mediated immunity
chemical synaptic transmission
memory
locomotory behavior
visual learning
regulation of cell proliferation
homoiothermy
dopamine catabolic process
norepinephrine biosynthetic process
catecholamine biosynthetic process
glucose homeostasis
fear response
maternal behavior
positive regulation of vasoconstriction
behavioral response to ethanol
response to pain
leukocyte migration
oxidation-reduction process
regulation of extrinsic apoptotic signaling pathway
associative learning
octopamine metabolic process
