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产品信息
PA5-72708
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Neucrin antibody for a 17 amino acid synthetic peptide near the carboxy terminus of human Neucrin. The immunogen is within the last 50 amino acids of NEUCRIN.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2718562
产品详细信息
Specificity: At least three isoforms of Neucrin are known to exist; this antibody will detect the two shorter isoforms. Neucrin antibody is predicted to not cross-react with RILP.
靶标信息
Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Dorsal inhibitory axon guidance protein; Dorsal repulsive axon guidance protein; Draxin; FLJ34999; MGC117222; Neucrin; neural tissue-specific cysteine-rich protein
基因别名: 2610109H07Rik; AGPA3119; C1orf187; DRAXIN; neucrin; PSEC0258; UNQ3119; UNQ3119/PRO10268
UniProt ID: (Human) Q8NBI3, (Mouse) Q6PAL1
Entrez Gene ID: (Human) 374946, (Rat) 691317, (Mouse) 70433
axon guidance
Wnt signaling pathway
dorsal spinal cord development
commissural neuron differentiation in spinal cord
negative regulation of axon extension
forebrain development
negative regulation of neuron apoptotic process
negative regulation of canonical Wnt signaling pathway
multicellular organism development
