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产品信息
PA5-52747
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2640854
产品详细信息
Immunogen sequence: DTTSSSSADS TIMDIQVPTR APDAVYTELQ PTSPTPTWPA DETPQPQTQT QQLEGTDGPL VTDPETHKST KAAHPTDDTT TLSERPSPST DVQTDPQTLK PSGFHEDDPF FYDEHTLR
Highest antigen sequence identity to the following orthologs: Mouse - 33%, Rat - 31%.
靶标信息
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 in variant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Dysadherin; FXYD domain-containing ion transport regulator 5; IWU-1; keratinocytes associated transmembrane protein 1
基因别名: DYSAD; FXYD5; HSPC113; IWU1; KCT1; OIT2; PRO6241; RIC; UNQ2561/PRO6241
UniProt ID: (Human) Q96DB9
Entrez Gene ID: (Human) 53827
