NeoBiotechnologies

Dystrophin (DMD) Monoclonal Antibody (DMD, 3243)

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Dystrophin (DMD) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Dystrophin (DMD) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Dystrophin (DMD) Antibody (1756-MSM3-P1) in IHC (P)

Immunohistochemistry (Paraffin) analysis performed in formalin fixed, paraffin-embedded human skeletal muscle using Dystrophin (DMD) Monoclonal Antibody (Product # 1756-MSM3-P1).

Dystrophin (DMD) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Dystrophin (DMD) Antibody in Peptide array (ARRAY)

Dystrophin (DMD) Antibody in SDS-PAGE (SDS-PAGE)

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Dystrophin (DMD) Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry (Paraffin) analysis performed in formalin fixed, paraffin-embedded human skeletal muscle using Dystrophin (DMD) Monoclonal Antibody (Product # 1756-MSM3-P1).

Dystrophin (DMD) Antibody in Peptide array (ARRAY) — Analysis of Protein Array containing more than 19,000 full-length human proteins Dystrophin (DMD) Monoclonal Antibody (Product # 1756-MSM3-P1). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (Monoclonal Antibody) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target, if the Monoclonal Antibody has an S-score of at least 2.5. For example, if a Monoclonal Antibody binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that Monoclonal Antibody to protein X is equal to 29.

Dystrophin (DMD) Antibody in SDS-PAGE (SDS-PAGE) — SDS-PAGE Analyis Purified Dystrophin (DMD) Monoclonal Antibody (Product # 1756-MSM3-P1). Confirmation of Purity and Integrity of Antibody.

产品信息

1756-MSM3-P1

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1-2 µg/mL

-

肽阵列 (Array)

Assay-dependent

-

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

DMD, 3243

抗原

A recombinant fragment (around aa 114-263) of human DMD protein

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.4, with 0.05% BSA

内含物

0.05% sodium azide

保存条件

4° C

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.

靶标信息

Dystrophin is the 427kDa protein product of the DMB/BMD gene located on the X chromosome at position Xp21. Western blotting and immunohistochemistry are the two established methods for the detection of abnormalities of dystrophin expression in muscle biopsies. Dystrophin abnormalities are thought to occur in 100% of patients with DMD/BMD, although genetic abnormalities may only be detected in up to 65% of cases.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Duchenne muscular dystrophy (DMD); Dystrophin; GS1-19O24.1; Muscular dystrophy Duchenne and Becker types; OTTHUMP00000215592

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基因别名: BMD; CMD3B; DMD; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272; MRX85

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UniProt ID: (Human) P11532

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Entrez Gene ID: (Human) 1756

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dystroglycan binding actin binding structural constituent of cytoskeleton protein binding zinc ion binding structural constituent of muscle myosin binding vinculin binding nitric-oxide synthase binding ubiquitin-protein ligase

regulation of heart rate cytoskeleton organization muscle organ development regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion regulation of skeletal muscle contraction muscle attachment muscle filament sliding negative regulation of peptidyl-serine phosphorylation cellular protein localization response to muscle stretch peptide biosynthetic process cellular protein complex assembly muscle cell cellular homeostasis muscle fiber development cardiac muscle contraction regulation of ryanodine-sensitive calcium-release channel activity cardiac muscle cell action potential regulation of voltage-gated calcium channel activity negative regulation of peptidyl-cysteine S-nitrosylation positive regulation of sodium ion transmembrane transporter activity