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产品信息
PA5-67167
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2663632
产品详细信息
Immunogen sequence: RHLKSLTPCTE KIRFSVSKDV VVSKEDARAG SGAGAAGLGT ATSSVTGEPI ETSPVIHLVT DAKGTVIHEV HVQM
Highest antigen sequence identity to the following orthologs - mouse 77%, rat 79%.
靶标信息
May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.; FUNCTION: Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional activation and repression of viral genes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: E4F transcription factor 1; p120E4F; p50E4F; Putative E3 ubiquitin-protein ligase E4F1; RING-type E3 ubiquitin transferase E4F1; Transcription factor E4F; Transcription factor E4F1
基因别名: E4F; E4F1
UniProt ID: (Human) Q66K89
Entrez Gene ID: (Human) 1877
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
transcription corepressor activity
protein binding
ligase activity
cAMP response element binding
metal ion binding
C2H2 zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
DNA replication
transcription, DNA-templated
mitotic nuclear division
cell proliferation
regulation of mitotic cell cycle, embryonic
regulation of cell cycle process
viral process
protein ubiquitination
regulation of growth
cell division
mitotic cell cycle arrest
