Invitrogen

EAF2 Polyclonal Antibody

EAF2 Antibody in Immunohistochemistry (IHC)

图: 1 / 5

EAF2 Antibody (PA5-52557) in IHC

Immunohistochemical staining of EAF2 in human tonsil using an EAF2 Polyclonal Antibody (Product # PA5-52557) shows strong nuclear positivity in germinal center cells.

Product Image Gallery

EAF2 Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of EAF2 demonstrates antibody specificity. Immunohistochemical analysis of EAF2 using anti-EAF2 Polyclonal Antibody (Product # PA5-52557), shows significant staining of EAF2 in human tonsil and shows minimal or weak staining in human pancreas tissues. The relative expression levels of EAF2 within each tissue is shown using RNA-Seq. {RE}

产品信息

PA5-52557

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

免疫组化（石蜡） (IHC (P))

1:200-1:500

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human EAF2. Recombinant protein control fragment (Product #RP-89676).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2640861

产品详细信息

Immunogen sequence: GFSHLDRRER VLKLGESFEK QPRCAFHTVR YDFKPASIDT SSEGYLEVGE GEQVTITLPN IEGSTPPVTV FKGSKKPYLK ECILIINHDT GECRL

Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 89%.

靶标信息

EAF1 and EAF2 can form a complex with ELL that targets the ternary elongation complex of Pol II, stimulating the rate of elongation. In addition, EAF1 and EAF2 are important for the stability of the NuA4 histone acetyltransferase complex, which transcriptionally activates certain genes by acetylation of Histones H4 and H2A. Both EAF1 and EAF2 are ubiquitously expressed members of the EAF family that colocalize with ELL to the the Cajal bodies and nuclear speckles. EAF1 contains a C-terminal region rich in aspartic acid, glutamic acid and serine residues. EAF2 is an androgen-response gene and can act as a potent apoptosis inducer.

仅用于科研。不用于诊断过程。未经明确授权不得转售。