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产品信息
PA5-31609
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 64 and 258 of Human SNF8
偶联物
形式
Liquid
浓度
0.68 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2549082
产品详细信息
Recommended positive controls: A549, HeLa, HepG2, HCT116.
Predicted reactivity: Mouse (98%), Rat (99%), Zebrafish (82%), Xenopus laevis (84%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
ELL encodes an RNA polymerase II transcription factor that undergoes frequent translocation in acute myeloid leukemia (AML). In addition to its elongation activity, ELL contains a novel type of RNA polymerase II interaction domain that is capable of repressing polymerase activity in promoter-specific transcription. EAP30 is a subunit of the ELL complex. EAP30 can interact with ELL and derepress ELL's inhibitory activity in vitro.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: EAP30 subunit of ELL complex; ELL-associated protein of 30 kDa; ESCRT-II complex subunit VPS22; hVps22; SNF8, ESCRT-II complex subunit, homolog; Vacuolar-sorting protein SNF8
基因别名: Dot3; EAP30; SNF8; VPS22
UniProt ID: (Human) Q96H20
Entrez Gene ID: (Human) 11267
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
autophagy
positive regulation of gene expression
regulation of multivesicular body size involved in endosome transport
endosomal transport
endocytic recycling
multivesicular body assembly
regulation of protein catabolic process
protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
regulation of MAP kinase activity
early endosome to late endosome transport
positive regulation of protein catabolic process
regulation of protein complex stability
multivesicular body sorting pathway
positive regulation of exosomal secretion
regulation of viral budding via host ESCRT complex
