Invitrogen

ECM1 Polyclonal Antibody

ECM1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ECM1 Antibody (PA5-82960) in IHC (P)

Immunohistochemical analysis of ECM1 in human testis using ECM1 Polyclonal Antibody (Product # PA5-82960) shows no positivity in cells in seminiferous ducts as expected.

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ECM1 Antibody — Relative expression in western blot: Antibody specificity was demonstrated by detection of known differential basal expression of the target across tissue/cell models. Expression of ECM1 was observed specifically in SK-MEL-30 cells and in MCF-7 cells using anti-ECM1 Polyclonal Antibody (Product #PA5-82960) in western blot. The relative expression levels of ECM1 within each cell line is shown using RNA-Seq. {RE}

产品信息

PA5-82960

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

免疫组化（石蜡） (IHC (P))

1:200-1:500

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human ECM1. Recombinant protein control fragment (Product #RP-89165).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2790116

产品详细信息

Immunogen sequence: EDTLDKYCDR EYAVKTHHHL CCRHPPSPTR DECFARRAPY PNYDRDILTI DIGRVTPNLM GHLCGNQRVL TKHKHIPGLI HNMTARCCDL PFPEQACCAE EEKLTFINDL CGPRRNIWRD PALCCYLSPG DEQVNCFNIN YLRNVALVS

靶标信息

ECM1, also referred to as extracellular matrix protein 1, is a protein that plays a significant role in regulating extracellular matrix organization and cell adhesion. It is expressed in various tissues, including the skin, lung, and liver, and is involved in the development and progression of several diseases, including cancer and dermatological disorders. The protein interacts with several extracellular matrix proteins, such as collagen and fibronectin, and is involved in the regulation of cell proliferation, migration, and invasion. ECM1 is also involved in endochondral bone formation, angiogenesis, and tumor biology. It interacts with various extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae, and certain viscera. Different isoforms of ECM1 have been described in alternatively spliced transcript variants. Diseases associated with ECM1 include Lipoid Proteinosis Of Urbach And Wiethe and Lichen Sclerosus Et Atrophicus.

仅用于科研。不用于诊断过程。未经明确授权不得转售。