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产品信息
PA5-59938
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.06 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2640881
产品详细信息
Immunogen sequence: TKDEDYGCVP CPAEKFSKGG YQICRRHKDC EGFFRATVLT PGDMENDAEC GPCLPGYYML ENRPRNIYGM VCYSCLLAPP NTKECVGATS GASANFPGTS
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 95%.
靶标信息
This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia.
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生物信息学
蛋白别名: Anhidrotic ectodysplasin receptor 1; Downless homolog; downless, mouse, homolog of; Ectodermal dysplasia receptor; ectodysplasin 1, anhidrotic receptor; Ectodysplasin-A receptor; EDA-A1 receptor; Tumor necrosis factor receptor superfamily member EDAR
基因别名: DL; ECTD10A; ECTD10B; ED1R; ED3; ED5; EDA-A1R; EDA1R; EDA3; EDAR; HRM1
UniProt ID: (Human) Q9UNE0
Entrez Gene ID: (Human) 10913
hair follicle development
apoptotic process
epidermis development
positive regulation of gene expression
cell differentiation
tumor necrosis factor-mediated signaling pathway
positive regulation of NF-kappaB import into nucleus
odontogenesis of dentin-containing tooth
positive regulation of I-kappaB kinase/NF-kappaB signaling
pigmentation
positive regulation of JNK cascade
salivary gland cavitation
