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EDAR Antibody (MA5-51876) in ICC/IF
Immunocytochemistry analysis of EDAR in paraformaldehyde fixed A549 cells , permeabilized with 0.15% Triton using EDAR Recombinant Mouse Monoclocal Antibody (Product # MA5-51876) at 10 µg/mL for 1h followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing weak membrane staining. The nuclear stain is DAPI (blue). Panels show from left-right, top-bottom: primary antibody, DAPI, merged channels and an isotype control. The isotype control was stained with an unknown specificity antibody (Product # MA5-47823) followed by Alexa Fluor488 ... View More
产品信息
MA5-51876
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog,
Chicken,
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
EDAR12
抗原
EDAR12 was prepared by immunixzing female OVE1B mice (with the Edar gene deleted) subcutaneously with mouse EDAR-Fc and positive hybridoma clones were screened for binding mEDAR by ELISA.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
EDAR12 recognises and binds to CRD1 of the extracellular domain of mouse EDAR. EDAR3 cross-reacts with EDAR derived from human, dog, rat and chicken when EDAR is fused to the glycosylphosphatidylinositol anchor of TRAILR3. EDAR is the receptor for the TNF family ligand EDA1, which is a type II transmembrane protein possessing a collagen-like domain and a C-terminal TNF-homology domain. EDAR is important for the correct development of skin appendages including hair, teeth and eccrine sweat glands. LoF mutations in the Eda gene is known to cause XLHED (X-linked hypohidrotic ectodermal dysplasia), and results in abnormal development.
靶标信息
This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Anhidrotic ectodysplasin receptor 1; Downless; Downless homolog; downless, mouse, homolog of; Ectodermal dysplasia receptor; ectodysplasin 1, anhidrotic receptor; ectodysplasin A1 receptor; Ectodysplasin-A receptor; EDA-A1 receptor; receptor for tumor necrosis factor superfamily member ectodysplasin A1; Tumor necrosis factor receptor superfamily member EDAR
基因别名: DL; ECTD10A; ECTD10B; ED1R; ED3; ED5; EDA-A1R; EDA1R; EDA3; EDAR; HRM1; RGD1561714
UniProt ID: (Human) Q9UNE0, (Mouse) Q9R187
Entrez Gene ID: (Human) 10913, (Dog) 481305, (Chicken) 428015, (Rat) 365581, (Mouse) 13608
hair follicle development
apoptotic process
epidermis development
positive regulation of gene expression
cell differentiation
tumor necrosis factor-mediated signaling pathway
positive regulation of NF-kappaB import into nucleus
odontogenesis of dentin-containing tooth
positive regulation of I-kappaB kinase/NF-kappaB signaling
pigmentation
positive regulation of JNK cascade
salivary gland cavitation
signal transduction
biological_process
multicellular organism development
