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产品信息
IHC-00025
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 600 and 650 of human E3 Ubiquitin Protein Ligase, HECT domain containing 1.
偶联物
形式
Liquid
浓度
0.10 mg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.0 to 8.0, with 0.1% BSA
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, X. tropicalis, Chicken, Turkey, Bovine, Dog, Horse, Pig, Panda, Orangutan, Monkey, Gorilla and Chimpanzee
靶标信息
EDD (for E3 identified by Differential Display) is a progestin-regulated gene that was isolated from T-47D human breast cancer cells. Based on sequence homology, EDD appears to be a human homolog of the Drosophila hyperplastic discs (hyd) gene, a tumor suppressor gene that is required for control of imaginal disc growth. EDD contains a HECT domain in the carboxy terminus. HECT domain-containing proteins function as ubiquitin-protein ligases, or E3 enzymes. EDD has been shown to bind to ubiquitin, and like other HECT family proteins, may function as an E3 ubiquitin-protein ligase.
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生物信息学
蛋白别名: CH D1S3362; E3 identified by differential display; E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase, HECT domain-containing 1; ECGF1; EDG-1; EDG1; hHYD; Hyperplastic discs protein homolog; Progestin-induced protein; S1P receptor 1; S1P receptor Edg-1; S1P1; S1PR1
基因别名: DD5; EDD; EDD1; HYD; KIAA0896; UBR5
UniProt ID: (Human) O95071
Entrez Gene ID: (Human) 51366
protein polyubiquitination
DNA repair
ubiquitin-dependent protein catabolic process
cellular response to DNA damage stimulus
cell proliferation
positive regulation of protein import into nucleus, translocation
positive regulation of catenin import into nucleus
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
progesterone receptor signaling pathway
positive regulation of canonical Wnt signaling pathway
negative regulation of histone H2A K63-linked ubiquitination
negative regulation of double-strand break repair
