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产品信息
PA1-1041
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat,
Xenopus
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues L(348) N H T I L A G V H S N D H S V V(364) of human LPA1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 1mg/mL BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2135264
产品详细信息
PA1-1041 detects lysophosphatidic acid receptor 1 protein in rat, human, mouse, and Xenopus samples.
PA1-1041 has successfully been used in Western blot procedures. By Western blot, this antibody detects an ~42 kDa protein representing lysophosphatidic acid receptor 1 in PC12 and HeLa whole cell lysates as well as mouse and Xenopus liver samples.
The PA1-1041 immunogen is a synthetic peptide corresponding to residues L(348) N H T I L A G V H S N D H S V V(364) of human LPA1. The immunizing sequence is completely conserved in human, mouse, rat and bovine. This peptide (Cat. # PEP-233) is available for use in neutralization and control experiments.
靶标信息
EDG2 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids There are eight known members of the EDG receptor family and they are implicated in mediating growth-related effects such as induction of cellular proliferation, alterations in differentiation and survival, and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: endothelial differentiation lysophosphatidic acid G-protein-coupled receptor 2; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2; G-protein coupled receptor 26; LPA receptor 1; LPA-1; Lysophosphatidic acid receptor 1; Lysophosphatidic acid receptor Edg-2; Rec1.3; ventricular zone gene 1; VZG-1
基因别名: AI326300; edg-2; EDG2; Gpcr26; Gpcr91; GPR26; Kdt2; LPA1; LPAR1; Mrec1.3; rec.1.3; vzg-1; VZG1
UniProt ID: (Human) Q92633, (Rat) P61794, (Mouse) P61793
Entrez Gene ID: (Human) 1902, (Rat) 116744, (Mouse) 14745
activation of MAPK activity
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
activation of phospholipase C activity
positive regulation of cytosolic calcium ion concentration
regulation of cell shape
negative regulation of neuron projection development
oligodendrocyte development
cerebellum development
optic nerve development
corpus callosum development
negative regulation of cAMP biosynthetic process
bleb assembly
positive regulation of Rho protein signal transduction
myelination
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
positive regulation of stress fiber assembly
cell chemotaxis
positive regulation of dendritic spine development
cellular response to oxygen levels
positive regulation of smooth muscle cell chemotaxis
cellular response to 1-oleoyl-sn-glycerol 3-phosphate
positive regulation of cell death
neurogenesis
signal transduction
