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EDG3 Antibody (H00001903-B01P) in WB
Western Blot analysis of S1PR3 expression in transfected 293T cell line (H00001903-T01) by S1PR3 MaxPab polyclonal antibody.
Lane 1: EDG3 transfected lysate(41.58 KDa).
Lane 2: Non-transfected lysate.
Lane 1: EDG3 transfected lysate(41.58 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00001903-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
EDG3 (NP_005217.2, 1 a.a. approximately 378 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MATALPPRLQ PVRGNETLRE HYQYVGKLAG RLKEASEGST LTTVLFLVIC SFIVLENLMV LIAIWKNNKF HNRMYFFIGN LALCDLLAGI AYKVNILMSG KKTFSLSPTV WFLREGSMFV ALGASTCSLL AIAIERHLTM IKMRPYDANK RHRVFLLIGM CWLIAFTLGA LPILGWNCLH NLPDCSTILP LYSKKYIAFC ISIFTAILVT IVILYARIYF LVKSSSRKVA NHNNSERSMA LLRTVVIVVS VFIACWSPLF ILFLIDVACR VQACPILFKA QWFIVLAVLN SAMNPVIYTL ASKEMRRAFF RLVCNCLVRG RGARASPIQP ALDPSRSKSS SSNNSSHSPK VKEDLPHTAP SSCIMDKNAA LQNGIFCN
靶标信息
EDG-3 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-3 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-3 is expressed in cardiovascular, leukocyte-containing and other tissues.
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生物信息学
蛋白别名: Endothelial differentiation G-protein coupled receptor 3; endothelial differentiation, sphingolipid G-protein-coupled receptor, 3; FLJ37523; FLJ93220; G protein-coupled receptor, endothelial differentiation gene-3; MGC71696; S1P receptor 3; S1P receptor Edg-3; S1P receptor EDG3; S1P receptor S1P3; sphingosine; Sphingosine 1-phosphate receptor 3; Sphingosine 1-phosphate receptor Edg-3
基因别名: C9orf108; C9orf47; EDG-3; EDG3; LPB3; S1P3; S1PR3
UniProt ID: (Human) Q99500
Entrez Gene ID: (Human) 1903
cytokine production
sphingosine-1-phosphate signaling pathway
inflammatory response
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
Notch signaling pathway
positive regulation of cell proliferation
anatomical structure morphogenesis
regulation of interleukin-1 beta production
negative regulation of establishment of endothelial barrier
