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EEF1E1 Antibody (PA5-114832) in IHC (P)
Immunohistochemistry analysis of EEF1E1 in human pancreatic cancer and adjacent normal tissues. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-114832) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
产品信息
PA5-114832
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human EEF1E1(Accession O43324), corresponding to amino acid residues M1-T42.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2899468
产品详细信息
Antibody detects endogenous levels of total AIMP3/p18.
靶标信息
This gene encodes a multifunctional protein that localizes both in the cytoplasm and in the nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage and plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3; ARS-interacting multifunctional protein 3; Elongation factor p18; Eukaryotic translation elongation factor 1 epsilon-1; Multisynthase complex auxiliary component p18; multisynthetase complex auxiliary component p18; p18 component of aminoacyl-tRNA synthetase complex
基因别名: 1110003A02Rik; AIMP3; EEF1E1; P18
UniProt ID: (Human) O43324, (Mouse) Q9D1M4
Entrez Gene ID: (Human) 9521, (Mouse) 66143, (Rat) 291057
translational elongation
tRNA aminoacylation for protein translation
glutathione metabolic process
negative regulation of cell proliferation
positive regulation of apoptotic process
positive regulation of DNA damage response, signal transduction by p53 class mediator
positive regulation of cellular senescence
DNA repair
translation
embryo development
positive regulation of apoptotic signaling pathway
