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产品信息
PA5-55722
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2640895
产品详细信息
Immunogen sequence: LSLLEKSLGL SKGNKYSAQG ERQIPVLQTN NGPSLTGLTT IAAHLVKQAN KEYLLGSTAE EKAIVQQWLE YRVTQVDGHS SKNDIHTLLK DL
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 83%.
靶标信息
This gene encodes a multifunctional protein that localizes both in the cytoplasm and in the nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage and plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants.
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生物信息学
蛋白别名: Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3; ARS-interacting multifunctional protein 3; Elongation factor p18; Eukaryotic translation elongation factor 1 epsilon-1; Multisynthase complex auxiliary component p18; p18 component of aminoacyl-tRNA synthetase complex
基因别名: AIMP3; EEF1E1; P18
UniProt ID: (Human) O43324
Entrez Gene ID: (Human) 9521
translational elongation
tRNA aminoacylation for protein translation
glutathione metabolic process
negative regulation of cell proliferation
positive regulation of apoptotic process
positive regulation of DNA damage response, signal transduction by p53 class mediator
positive regulation of cellular senescence
