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产品信息
PA5-58493
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2640910
产品详细信息
Immunogen sequence: PDGRVVSRPQ RLGQGSGQGP KGSGACLHPL DSLEQKETQE QTSGQLVMLR KAQEFFQTCD AEGKGFIARK DMQRLHKELP LSLEELEDVF DALDA
Highest antigen sequence identity to the following orthologs: Mouse - 60%, Rat - 59%.
靶标信息
CRACR2A is a Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. CRACR2A acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. Further, CRACR2A regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, CRACR2A dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
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生物信息学
蛋白别名: Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A; Calcium release-activated calcium channel regulator 2A; Calcium release-activated channel regulator 2A; CRAC channel regulator 2A; CRAC regulator 2A; EF-hand calcium binding domain 4B; EF-hand calcium-binding domain-containing protein 4B; Ras-related protein Rab-46
基因别名: CRACR2A; EFCAB4B; RAB46
UniProt ID: (Human) Q9BSW2
Entrez Gene ID: (Human) 84766
