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产品信息
PA5-85460
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human EFCAB4B.
偶联物
形式
Liquid
浓度
0.56 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2792600
产品详细信息
Keep as concentrated solution.
Positive Control: A431.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
CRACR2A is a Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. CRACR2A acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. Further, CRACR2A regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, CRACR2A dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A; Calcium release-activated calcium channel regulator 2A; Calcium release-activated channel regulator 2A; CRAC channel regulator 2A; CRAC regulator 2A; EF-hand calcium binding domain 4B; EF-hand calcium-binding domain-containing protein 4B; Ras-related protein Rab-46
基因别名: CRACR2A; EFCAB4B; RAB46
UniProt ID: (Human) Q9BSW2
Entrez Gene ID: (Human) 84766
