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产品信息
PA5-85447
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human EFHA1.
偶联物
形式
Liquid
浓度
1.92 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2792587
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Mouse (85%), Rat (84%), Bovine (81%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium. MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Calcium uptake protein 2, mitochondrial; EF hand domain family A1; EF hand domain family, member A1; EF-hand domain family member A1; EF-hand domain family, member A1; EF-hand domain-containing family member A1; hMICU3; Smhs2 homolog
基因别名: 09C01; 1110008L20Rik; 4833427E09Rik; AU041871; EFHA1; MICU2; RGD1309934; Smhs2
UniProt ID: (Human) Q8IYU8, (Rat) Q99P63, (Mouse) Q8CD10
Entrez Gene ID: (Human) 221154, (Rat) 171433, (Mouse) 68514
