NeoBiotechnologies

EGFRvIII (Epidermal Growth Factor Receptor, Variant III) Recombinant Rabbit Monoclonal Antibody (GFR/2600R)

Questions & Answers

Questions & Answers

抗体检测数据 (3)

EGFRvIII (Epidermal Growth Factor Receptor, Variant III) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

EGFRvIII (Epidermal Growth Factor Receptor, Variant III) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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EGFRvIII (Epidermal Growth Factor Receptor, Variant III) Antibody (1956-RBM13-P0) in IHC (P)

Formalin-fixed, paraffin-embedded human Lung SqCC stained with EGFRvIII Rabbit Recombinant Monoclonal Antibody (GFR/2600R).

EGFRvIII (Epidermal Growth Factor Receptor, Variant III) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

EGFRvIII (Epidermal Growth Factor Receptor, Variant III) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

EGFRvIII (Epidermal Growth Factor Receptor, Variant III) Antibody in SDS-PAGE (SDS-PAGE)

Product Image Gallery

EGFRvIII (Epidermal Growth Factor Receptor, Variant III) Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Formalin-fixed, paraffin-embedded human Lung SqCC stained with EGFRvIII Rabbit Recombinant Monoclonal Antibody (GFR/2600R).

EGFRvIII (Epidermal Growth Factor Receptor, Variant III) Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Formalin-fixed, paraffin-embedded human Placenta stained with EGFRvIII Rabbit Recombinant Monoclonal Antibody (GFR/2600R).

EGFRvIII (Epidermal Growth Factor Receptor, Variant III) Antibody in SDS-PAGE (SDS-PAGE) — SDS-PAGE analysis Purified EGFRvIII Rabbit Recombinant Monoclonal Antibody (GFR/2600R). Confirmation of Integrity and Purity of Antibody.

产品信息

1956-RBM13-P0

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

Assay-dependent

-

免疫组织化学（多聚甲醛固定） (IHC (PFA))

1-2 µg/mL

-

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

GFR/2600R

抗原

KLH conjugate of EGFRvIII-specific, 14-amino acid peptide from the predicted amino acid sequence at the fusion junction (LEEKKGNYVVTDHC)

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.4, with 0.05% BSA

内含物

0.05% sodium azide

保存条件

4° C, do not freeze

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; Epidermal growth factor receptor; erb-b2 receptor tyrosine kinase 1; Erbb1 variant III; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1

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基因别名: EGFR; ERBB; ERBB1; HER1; mENA; NISBD2; PIG61

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UniProt ID: (Human) P00533

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Entrez Gene ID: (Human) 1956

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chromatin binding double-stranded DNA binding MAP kinase kinase kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor signaling protein tyrosine kinase activity transmembrane signaling receptor activity epidermal growth factor-activated receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding enzyme binding protein phosphatase binding nitric-oxide synthase regulator activity ubiquitin protein ligase binding identical protein binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity protein heterodimerization activity actin filament binding cadherin binding involved in cell-cell adhesion transmembrane signal receptor

MAPK cascade activation of MAPKK activity cell morphogenesis ossification embryonic placenta development positive regulation of protein phosphorylation hair follicle development response to stress signal transduction cell surface receptor signaling pathway epidermal growth factor receptor signaling pathway activation of phospholipase C activity salivary gland morphogenesis learning or memory cell proliferation positive regulation of cell proliferation regulation of phosphatidylinositol 3-kinase signaling single organismal cell-cell adhesion peptidyl-tyrosine phosphorylation cerebral cortex cell migration positive regulation of cell growth positive regulation of cell migration positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle positive regulation of catenin import into nucleus ERBB2 signaling pathway negative regulation of epidermal growth factor receptor signaling pathway negative regulation of protein catabolic process positive regulation of phosphorylation activation of phospholipase A2 activity by calcium-mediated signaling negative regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of GTPase activity positive regulation of nitric oxide biosynthetic process positive regulation of DNA repair positive regulation of DNA replication positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling positive regulation of fibroblast proliferation digestive tract morphogenesis positive regulation of epithelial cell proliferation regulation of peptidyl-tyrosine phosphorylation regulation of nitric-oxide synthase activity protein insertion into membrane positive regulation of protein kinase B signaling morphogenesis of an epithelial fold eyelid development in camera-type eye response to UV-A positive regulation of ERK1 and ERK2 cascade cellular response to amino acid stimulus cellular response to epidermal growth factor stimulus cellular response to estradiol stimulus positive regulation of production of miRNAs involved in gene silencing by miRNA regulation of cell motility