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EGR2 Antibody (MA5-50133) in WB
Western blot analysis of EGR2 in SY5Y whole cell lysate, U251 whole cell lysate, MCF7 whole cell lysate, K562 whole cell lysate, Mouse Brain tissue lysate, Mouse Brain tissue lysate using a dilution of 1:1,000. Samples were incubated with EGR2 monoclonal antibody (Product # MA5-50133). Secondary: Goat polyclonal to rabbit IgG at 1:50,000 dilution. Predicted band size: 50 kDa. Observed band size: 50 kDa.
产品信息
MA5-50133
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
27C3
抗原
A synthesized peptide derived from Human EGR2
偶联物
形式
Liquid
浓度
1.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_3093697
靶标信息
The EGR2 gene provides instructions for making a protein called early growth response 2, which is part of the early growth response family of proteins. These proteins bind to specific areas of DNA and help control the activity of particular genes. On the basis of this action, the proteins are referred to as transcription factors. The early growth response 2 protein activates several genes that are involved in the formation and maintenance of myelin, the fatty substance that covers and protects nerve cells. Myelin promotes the efficient transmission of nerve impulses. If myelin is lost (demyelination) or its structure is disrupted, the transmission of nerve impulses is impaired. Mutations in the EGR2 gene can cause two forms of Charcot-Marie-Tooth disease, type 1D or type 4E (sometimes called congenital hypomyelinating neuropathy) or a severe form of type 1D (sometimes called Dejerine-Sottas syndrome) that begins during infancy or early childhood.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AT591; DKFZp686J1957; E3 SUMO-protein ligase EGR2; E3 SUMO-protein transferase ERG2; Early growth response protein 2; EGR-2; FLJ1454; FLJ14547; Krox-20 homolog; KROX-20, Drosophila, homolog (early growth response-2); OTTHUMP00000062133; Zinc finger protein Krox-20
基因别名: AT591; CMT1D; CMT4E; Egr-2; EGR2; Krox-20; KROX20; NGF1-B; Zfp-25; Zfp-6
UniProt ID: (Human) P11161, (Mouse) P08152
Entrez Gene ID: (Human) 1959, (Mouse) 13654
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II activating transcription factor binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
ligase activity
ubiquitin protein ligase binding
transcription regulatory region DNA binding
metal ion binding
HMG box domain binding
nucleic acid binding
DNA binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
C2H2 zinc finger transcription factor
transcription from RNA polymerase II promoter
protein export from nucleus
brain development
peripheral nervous system development
learning or memory
rhythmic behavior
motor neuron axon guidance
Schwann cell differentiation
protein sumoylation
facial nerve structural organization
rhombomere 3 formation
rhombomere 5 formation
regulation of ossification
response to insulin
brain segmentation
skeletal muscle cell differentiation
myelination
fat cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of neuronal synaptic plasticity
cellular response to organic substance
transcription, DNA-templated
regulation of transcription, DNA-templated
rhombomere 3 development
negative regulation of apoptotic process
cellular response to cAMP
cellular response to gonadotropin stimulus
