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EHHADH Antibody (PA5-101741) in IHC (P)
Immunohistochemistry analysis of EHHADH in human colorectal cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with EHHADH polyclonal antibody (Product # PA5-101741) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-101741
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human EHHADH(Accession Q08426), corresponding to amino acid residues N475-A525.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2851174
产品详细信息
Antibody detects endogenous levels of total EHHADH.
靶标信息
As an L-hydroxy-specific enzyme, EHHADH (enoyl-CoA-hydratase:3-hydroxyacyl-CoA dehydrogenase), also known as Peroxisomal L-bifunctional enzyme, is a 723 amino acid protein has an essential tripeptide sequence on its carboxyl-terminus that is required for peroxisomal transport. EHHADH-null mice only exhibit a blunted peroxisome proliferative response when challenged with a peroxisome proliferator. Since there were no observed changes in lipid metabolism, this evidence suggests that enoyl-CoAs were diverted to the D-hydroxy-specific beta-oxidation system for metabolism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 3,2-trans-enoyl-CoA isomerase; enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase; L-3-hydroxyacyl-CoA dehydrogenase; L-bifunctional enzyme; L-bifunctional protein; L-bifunctional protein, peroxisomal; L-PBE; L-peroxisomal bifunctional enzyme; L-specific bifunctional protein; L-specific multifunctional beta-oxdiation protein; LBP; MFE1; MFP-1; MFP1; Multifunctional enzyme 1; multifunctional enzyme type 1; Multifunctional protein 1; PBE; Peroxisomal bifunctional enzyme; peroxisomal bifunctional enzyme type 1; peroxisomal enoyl-CoA hydratase
基因别名: ECHD; EHHADH; HD; LBFP; LBP; MEF; Mfe; MFP; Pbe; PBFE; 1; 1300002P22Rik; FRTS3; L-PBE; Mfe1; MFP1; perMFE-1
UniProt ID: (Human) Q08426, (Mouse) Q9DBM2, (Rat) P07896
Entrez Gene ID: (Human) 1962, (Mouse) 74147, (Rat) 171142
3-hydroxyacyl-CoA dehydrogenase activity
dodecenoyl-CoA delta-isomerase activity
enoyl-CoA hydratase activity
receptor binding
protein binding
long-chain-enoyl-CoA hydratase activity
enzyme binding
catalytic activity
oxidoreductase activity
lyase activity
isomerase activity
coenzyme binding
dehydrogenase
