Invitrogen

EIF2A Polyclonal Antibody

EIF2A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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EIF2A Antibody (PA5-41916) in IHC (P)

Immunohistochemistry (paraffin-embedded) analysis of human skin tissue using an anti-eIF2 alpha polyclonal antibody (Product # PA5-41916).

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产品信息

PA5-41916

应用

建议稀释比

已发表文章

免疫印迹 (WB)

2.5 µg/mL

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免疫组化（石蜡） (IHC (P))

4-8 µg/mL

产品规格

种属反应

Human

已发表种属

Mouse, Yeast, Zebrafish

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide directed towards the C-terminal of human EIF2A (aa 504-553).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2609709

产品详细信息

Peptide sequence: DKSPDLAPTP APQSTPRNTV SQSISGDPEI DKKIKNLKKK LKAIEQLKEQ

Sequence homology: Cow: 86%; Dog: 100%; Goat: 83%; Guinea Pig: 93%; Horse: 86%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 100%; Zebrafish: 93%

靶标信息

EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Induction of proteasomal activity in mammalian cells by lifespan-extending tRNA synthetase inhibitors.

GeroScience

Mariner BL,Rodriguez AS,Heath OC,McCormick MA

PA5-41916 was used in Western Blot to show that multiple tRNA synthetase inhibitors can greatly upregulate activity of the ubiquitin proteasome system (UPS) in cells in an ATF4-dependent manner.

Mon Apr 01 00:00:00 UTC 2024

Genetic landscape of T cells identifies synthetic lethality for T-ALL.

Communications biology

O'Meara CP,Guerri L,Lawir DF,Mateos F,Iconomou M,Iwanami N,Soza-Ried C,Sikora K,Siamishi I,Giorgetti O,Peter S,Schorpp M,Boehm T

PA5-41916 was used in Western Blot to delineate the genetic network underlying the development of T cells in zebrafish, establish the nature of synthetic lethal interactions, and inform combinatory inhibitor treatments in preventing progression of T-cell acute lymphoblastic leukaemia.

Wed Oct 20 00:00:00 UTC 2021

Magnesium depletion extends fission yeast lifespan via general amino acid control activation.

MicrobiologyOpen

Ohtsuka H,Kobayashi M,Shimasaki T,Sato T,Akanuma G,Kitaura Y,Otsubo Y,Yamashita A,Aiba H

PA5-41916 was used in Western Blot to investigate effects of magnesium on Schizosaccharomyces pombe lifespan.

Mon Mar 01 00:00:00 UTC 2021

生物信息学

蛋白别名: 65 kDa eukaryotic translation initiation factor 2A; eIF-2A; Eukaryotic translation initiation factor 2A; eukaryotic translation initiation factor 2A, 65kDa

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基因别名: CDA02; EIF-2A; EIF2A; MST089; MSTP004; MSTP089

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UniProt ID: (Human) Q9BY44

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Entrez Gene ID: (Human) 83939

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功能

tRNA binding translation initiation factor activity protein binding ribosome binding cadherin binding involved in cell-cell adhesion translation factor translation initiation factor translational protein

参与通路

translational initiation regulation of translation protein phosphorylation positive regulation of signal transduction SREBP signaling pathway ribosome assembly cell-cell adhesion