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产品信息
PA5-41987
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the C-terminal of human ELAC2 (aa 439-488).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2605791
产品详细信息
Peptide sequence: ITCNPEEFIV EALQLPNFQQ SVQEYRRSAQ DGPAPAEKRS QYPEIIFLGT
Sequence homology: Dog: 100%; Human: 100%; Mouse: 83%; Rat: 83%
靶标信息
ELAC2 encodes a protein that has a C-terminal domain with tRNA 3 processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: elaC homolog 2; ElaC homolog protein 2; elaC-like protein 2; Heredity prostate cancer protein 2; putative prostate cancer susceptibility protein HPC2/ELAC2; Ribonuclease Z 2; RNase Z 2; tRNA 3 endonuclease 2; tRNase Z (long form); tRNase Z 2; Zinc phosphodiesterase ELAC protein 2
基因别名: COXPD17; ELAC2; ELC2; HPC2
UniProt ID: (Human) Q9BQ52
Entrez Gene ID: (Human) 60528
